Mine runs 275/45-20 all-round, and handles like a dream. No tram lining, no adverse behaviour. No protrusion of the wheels from the bodywork (that would be unroadworthy here in Australia). BUT! Mine are 9.5's. 275's stretched out onto 10.5's would look dumb.

I run 45's because they have a higher load rating than 40's, which is important to me when towing my 5500lb caravan.

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Cheers,

Anthony