At the height im currently at I dont have an issue. The beauty of the e53 is the way the fender flare on a non IS model and even with the one over top how it is on an IS model, is plastic and the metal edge is higher, versus how it would be on a normal sedan you have metal right away.
Mine has rounded/ate away what is needed in terms of suspension travel- pretty much the top edge of the tire 3-4 inches across on the plastic from the inside, and after that since the wheel cambers more and more as it is compressed, the rest of the wheel well is very deep immediately after that.
Here is an example of the rear wheel from underneath-
Front wheel
This is fitment in front, as you can see the top level is tilted, the edge of the wheel slighty pokes out past flare but tire does not, i also have front lemans flares not the flat ones.
Rear fitment
Yes, i know my rear tires are bald. I ran them for 15-20k since new, they are directionals, so when i got my new wheels i had the rears flip mounted and good edge on the inside..
Im also very lowered and -2.5 camber on each side but my toe is zeroed out. Buying tires before winter hits however i cannot complain, with very aggressive driving i have about 35k on them. They are at about 1.5-2/32 at the moment.
Pic of how it sits-
