I'd be curious what's involved. The DME takes inputs from literally everywhere and sends signals back out to loads of stuff. Electronically, an E53 is pretty much an E39, so if someone has done an LS swap into a 5-series, that might be a worth investigating.

A guy in a British car club I belong to dropped an E36 M3/S52 engine into a TR6. It's an unbelievably clean transplant and looks like it was meant to be there.

__________________
12 E70 3.5i xDrive
03 E46 330i ZHP
01 E53 3.0i
98 E36 323is
12 Audi A4 Quattro
79 Triumph Spitfire
73 MGB