I know this has probably been discussed before and I did a search but nothing recent.

Where is the best and safest place to install an infant car seat? I bought a Uppababy Mesa and it supports LATCH and seat belt. I think the LATCH can only be used if installing on the sides seats. If installing in the middle I would need to use the seat belt. In terms of securing the base, would he LATCH be more effective than using the seat belt?