Wow, working with the wheel on seems doable, but with a lot of additional challenges. I always try to get as much of the kr@ out of the way as I can. Besides using jack stand will the suspension drop a few extra inches for more room. The greater the frustration level, the longer and/or the more expensive the project becomes. If using jack stands makes you nervous, also leave the floor jack (if that is what you are using) in place and locked while you work, and slide the tire under the vehicle just in case. Good luck, and have fun.