It appears the issue is in your OBD.INI or your INPA OBD2 interface itself. I've had several of those interfaces and I've never had to modify them in any way- some were chepo off ebay. The first interface light stays a steady green when connected to the vehicle's OBD2 port. Another light flashes red when INPA talks to the vehicle. I'm running Windows10 with the latest updates on Surface Pro and INPA etc apps have no issues at all. Here's what my OBD.INI looks like (note the highlighted):

[OBD]
Hardware=USB
RETRY=ON
Port=Com1
[UNIT_B]
Port=Com3
Hardware=OBD
[UNIT_H]
Port=Com9
Hardware=OBD
[UNIT_J]
Hardware=OBD
Port=Com11
[UNIT_A]
Port=Com2
Hardware=OBD
[UNIT_K]
Hardware=OBD
Port=Com12
[UNIT_N]
Port=Com15
Hardware=OBD
[UNIT_C]
Port=Com4
Hardware=OBD
[UNIT_L]
Port=Com13
Hardware=OBD
[UNIT_E]
Hardware=OBD
Port=Com6
[UNIT_O]
Port=Com16
Hardware=OBD
[UNIT_F]
Hardware=OBD
Port=Com7
[UNIT_M]
Port=Com14
Hardware=OBD
[UNIT_D]
Hardware=OBD
Port=Com5
[UNIT_G]
Hardware=OBD
Port=Com8
[UNIT_I]
Hardware=OBD
Port=Com10

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'05 E53 X5 4.4i, '97 E39 528, '07 E92 335i, '16 F86 X6M.