Definitely doable, and definitely a PITA. I imagine it’s the same job as the 4.4/4.6, which entails raising the motor up a few inches and dropping the subframe a few inches. The job can’t be done without doing both of these as the diff simply won’t come out/go back in without the clearance offered by doing both of these.

When I did it I put the car on jacktands on all four corners and used an engine hoist to raise the motor. Then I used floor jacks on either side of the subframe to slowly drop it just enough to maneuver the diff into place. The diffs are heavy so a helper to slide a couple bolts in to hold it would be helpful. Same for lowering the subframe gently and simultaneously on both sides if you use floor jacks. Easier if use a 2 post lift I imagine. Regardless, You are on your back bench pressing the diff into place.

The trickiest part with the 4.4 set up is not screwing up the diff to oil pan seal on the install. If you nick that flimsy little o ring while cursing and manhandling the diff to get it into place, it will leak. The 4.4 has a metal protective ring that gets installed over the o ring, but my experience was that it kept falling off the diff. Alignment needs to be perfect in the way in.

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Current
Original owner 2002 E53 X5 4.4i to 4.6i swap
2025 G06 X5 50e
Former
1972 Audi Fox
1986 Saab 900S
1996 BMW Z3
1998 BMW E36 M3 Sedan
2004 BMW E46 M3
2006 Audi A3 Quatro
1993 Mopar 318 Jeep Grand Cherokee
2015 V6 Jeep Grand Cherokee