It might also be a memory problem. Did you "move" everything from your old PC to your new PC using a image file (i.e. Norton Ghost)? If so, some of your old program settings may have been copied over. If your drives are mapped differently or your directory structure is different, those settings may no longer work.

Double check your cache and temporary file settings. Look in the Control Panel > System > Advanced > Performance > Settings > Advanced. Take a look at your virtual memory cache file - is it the right size? Does it exceed the available space on your hard drive? Is it mapped to the right drive?

While in the Systems>Advanced tab, also look at Environmental Variables. Are the TEMP and TMP settings is pointing to valid file directories?

Do the same for IE - Tools-Internet Options>Temporary Internet Files>Settings. Is your IE Temp cache pointing to a valid directory? Also check to see if enough HD space is allocated for temporary internet files.

I have McAfee Enterprise Edition on my office computer - it does not have antispyware - at least not the version I have. I have only antivirus and firewall protection. Are you sure you don't have any spyware reading all your files before you do?