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Originally Posted by fln8tive
I will be staying only one night in Venice, then migrating, and I am looking for suggestions on the best route out to Indio on Saturday morning. TIA.
Do I take "the" 405 to "the" 10, or just "the" 10?
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If you're leaving Saturday morning, I assume you're leaving pretty early. In that case you might just miss the typical traffic on "the" 10.

Since you're leaving from Venice it would make the most sense to take the straight shot on Interstate 10. It wouldn't make sense to go all the way north and then come back down.
Just make sure you're leaving early.
You might hook up with White05X3. He's in Marina Del Rey, I think. I'm not sure if he's leaving Saturday morning of Friday night.
EDIT: I just saw that you're leaving from Mullholland. In that case you might be just as close to taking the 405.
405-134-210-15-10.