Didnt check the specs but probably just a little weight savings, engine and suspension tuning due to the S in R6S like kawasaki with the zx-636r and the zx-6rr. A trackday version i'm sure.

Dont know about SANguru but i'm 6'2 and a good 210pounds if not more and it does get a little cramped behind the screen! I'm thinking harley or maybe a chopper as a next bike if i can afford it!