I currently use, and am satisfied with the Harmony One (upgraded from the 880), and the Harmony 720. If you do decide on a Logitech product, you'd be limited to the 890 or 1000 as you'd also need the range extender to "eliminate" the walls and floors. However, the fact that these remotes are so intuitive and easy to use might just make it worth your while. I have no real experience with other universal remotes, so forgive my litany on the Harmony remotes!

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I'll drink your poison if you fill the cup. You make me crazy, baby, don't let up.
Break Free, DMB 2006