Yep, I had that dreaded sore throat when I woke up Saturday morning, and I knew I was getting a cold. So, I took a DayQuill, and....nothing. Tylenol Severe Cold? Nothing. NyQuill? nothing. So, after advice from a friend, I tried Zicam, those little cotton swabs that you put in your nose. I really didn't think it would work, but half an hour later I was still tired and beat up by the cold, but ZERO symptoms. I now am in love with this stuff, not much symptoms now, but still have a cold.