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Originally Posted by yjansen
... If you wanna really do the cleaning, go into regedit and delete all those useless registry strings. I don't recommend doing this though if you don't really know what you're doing. But if you wanna give it a try, do a Start - Run, and type in regedit. Go to HKEY_CURRENT_USER and go down SOFTWARE tree. Delete all the folders in there that contains old uninstalled applications. Then go to HKEY_LOCAL_MACHINE and do the same...
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How is it going to help you if you just delete the folders from the Windows Registry hives? It will give you nothing but troubles, believe me. The Windows Registry is just a big old file and even if you delete this whole registry file, you would probably save less than 50 MB at best.
What you should do is go into the Control Panel and uninstall the programs that you don't use anymore. Don't just go to the C: drive or D: drive and delete the folders. You want to uninstall them (by way of Control Panel > Add and Remove Programs and select program to uninstall).