I vote for #3 (comfort seats with nappa).
I got #2 (comfort seats with perforated nevada leather) in mine.
I initially didn't want nappa for durability concerns. In general softer leather is easier to tear. The nappa in our MB S550 is pretty delicate, I accidentally made a small hole in it but a pen that I left in my back pocket the first day we brought it home.
I didn't feel the nappa for the BMW X5 until after I my ordered car was already built and waiting from transport. It feels more durable (than MB) and is very smooth and soft. Thus the added comfort and luxury would be a good trade-off for not having ventilated seats.
Ventilated seats are okay. They are on the loud side, but it doesn't bother me.
I'm still trying to figure out in what situation they work the best. On some hot days, they seem worthless while other hot days I'm very glad to have gotten them. I'm guessing that it might have to do with the amount of prespiration that's on ones back or how close you are to the seats.
I've noticed that when my shirt is wet in the back and I don't put my back against the seat, I can really feel the air cooling my back down! But when my back is dry and I lean back against the chair, it doesn't seem to feel like much. I don't regret getting them, but would be perfectly fine trading the ventilation feature for nappa instead.
What tips my vote now is that the black nevada seems to get dirty very easily! I constantly see grey dirt that seems to be on it! Much more prominent than black leathers in all cars that I've owned before. I'm guessing the smoother texture of the nappa would be less proned to holding onto dirt.