Anything is possible... Especially if you haven't changed them yet at 107k.

Also, since you apparently have a code reader... you can take the misfiring cylinders, switch the coil with a known good one (cyl. without misfire code stored) and the spark plug to another.... clear faults, drive it till they come back. See which one the misfire follows. If it stays put, swap the injector with another and try again. That's just one way to figure out what component is giving you the trouble.

But just changing the spark plugs is a safe place to start, simply because you're due for them at 100k anyways... and the whole spraying the hoses trick to find vacuum leaks works great with substantial vacuum leaks, but not with the smaller ones. The computer compensates for it really quick. If your code reader has "data flow" you can read the upstream O2 sensor voltages. At idle at operating temperature they should switch in the range between 0.2 and 0.8 volts about every second. spray it all down with the cleaner while reading this, when you hit the tiny little leak, the voltages will stick at 0.8 volts for a few seconds. That's how I gotta track them down sometimes...

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2003 4.6is