I just picked one up, a Canon 50D with 28-135mm IS lens. I went from a Rebel XTi to this 50D, it is a huge leap for me...
Wow....this is a great camera. I've owned and used several Canons P&S and Rebel XTI) and a couple of Nikons (P&S and Nikon N55) over the years and I think this is the fastest camera I've ever used. The 3.0" LCD screen has beautiful resolution and can actually be used to get a feel for how you're pictures look, it's as clear as a computer screen. Most of the menu functions are easy to find and change on the fly, which is nice and I like. This is a very very smart camera so for those who don't like to use manual settings the creative feature is nice as you can instantly control your apeture and shutter speed as well as get a screen capture before you take a shot to see what it looks like.
The 50D is very intuitive, not the least bit indimidating, and surprisingly easy to use considering the more advanced features Canon has put into it. I have not spent a lot of time learning all that this camera can do yet, but I am encouraged by the camera and it practically asks you do learn more about it...it wants you to take great pictures.