If future repair costs are a major concern, that would be enough for me to get rid of it immediately. With the amount of stuff I have repaired on mine with just over 60K miles, it would scare the heck out of me to own one of these with 6 digits on the ticker.

You can't go wrong with Japanese cars from a reliability standpoint. Everything i own that is Japanese has been extremely reliable even above 100K. Conversly, my X has been a reliability nightmare. I do agree that my X is more exciting to drive but not to the point where I would spend a significant amount of money to keep it on the road.

I will be trading up pretty soon too for another Lexus, not because of mileage concerns or more room but solely because I'm tired of working on it every other weekend.

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2010 Lexus RX350 still new
2003 BMW X5 3.0i w/sport package w/68K miles. (gone Thank God!)
2002 Dodge Ram 2500 4X4 cummins diesel w/198K miles, custom repo truck
2009 Scion tC w/46K miles
2007 Suzuki SV650 custom streetfighter
2000 Lexus GS400 w/165K miles