An in-dash radio module will not work in a navigation-equipped car. The in-dash radio does not know to subordinate itself and communicate with the nav computer. It assumes that it is the center of car's audio system.

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2000 E38 750iL Highline Edition, Upgraded with the lastest 2006 X5 Electronics
MKIV Navigation, 16:9 Display, Bluetooth, TV/Video with Backup Camera, Sirius, and Aux Input