I had two E53s. Both the 2001 4.4i and the 2005 4.4i were pretty trouble free. The '01 had the air conditioning issue and the the '05 had two window regulators go out. They were more annoyances than serious issues. I've also had a trouble free E70 and am now loving my X6 other than my check engine light coming on for the 3rd time.

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Current:
2016 X6 ///M Black Sapphire Metallic