I remember when I unplugged my MAF one time to troubleshoot a poor running condition I had. It would trip the Trans Failsafe program when unplugged. I don't know why but when I plugged it back in, Trans Failsafe would go off again. It appeared to me that the vehicle was not driveable with the MAF unplugged for this reason.

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2010 Lexus RX350 still new
2003 BMW X5 3.0i w/sport package w/68K miles. (gone Thank God!)
2002 Dodge Ram 2500 4X4 cummins diesel w/198K miles, custom repo truck
2009 Scion tC w/46K miles
2007 Suzuki SV650 custom streetfighter
2000 Lexus GS400 w/165K miles