You'll have to see if you can find what's listed for the E53 in the ETK (electronics parts catalog). Because the electronics on the E70 are more sophisticated requiring everything to be programmed, I"ll probably guess this model Sat Radio won't work on the E53.

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'10 X5 35d Titanium Silver
Saddle Brown Nevada Leather
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Dark Bambu Trim
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Heads Up Display
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'07 X5 3.0si
Monaco Blue / Beige Nevada interior
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Comfort Seats

'02 X5 3.0i
Toledo Blue / Grey Nevada interior
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6 CD Changer