Not really, just saying M64 will have more maintenance cost over M54 3.0 6-cylinder; but in general if you do 7500mile/6mo oil change the engine will last to 200k easy. I think Wally is about to eclipse 300k on his X5 3.0 soon.

Now other things like Trans, xfer case, air-spring, suspension may not reach that point w/o major overhaul.