Many of the NG (new generation) radios installed in the e53 may retain their settings after a "brief" loss of power.
The main things that will need to be reset are mentioned in the owners manual. They tend to be the individual settings like the OBC features programmed into the instrument cluster display, the sunroof (at least the early ones...not sure about the pano S/R)...Time & Date, etc.: (see POWER FAILURE)