Not really a pick up line, but my buddy did this once cuz he thought it would be a good ice breaker. Needless to say, he didn't get the girl, but her expression was priceless. And it was quite hilarious to a bunch of drunk guys.

My Friend: Hi, How are you?
Girl: Good and yourself?
Friend: I'm feeling unbelievably great!
Girl: Oh? Why is that?
Friend: Because I just started taking Valtrex and it's completely curbed my genital herpes outbreak.

I like this one although I've never had the chance to use it, "What's a nice girl like you doing in a dirty mind like mine?" If anyone uses this one, let me know if it worked.

i personally would take the hi how are you? good and your self? im feeling great! why is that? because you're here
but thats just my .02c

I know what you mean...I haven't used one in a long time and my best one now is, "Baby, I need a fluffer."

yeah, but we were young and I think my friend was going for shock value.

haha thats funny though.

"The only way that that dress could look any better than on you, would be if it were crumpled up in a ball on the floor next to my bed"

"Can I borrow a quarter?"
"why?"
"My mother told me to call home if I ever fell in love"

There are always those "Is your father a..." lines.

Guy: Is your father a thief?
Girl: No. Why?
Guy: Then who stole the stars from the skies and put them in your eyes?

Guy: Is your father a baker?
Girl: No.
Guy: Well you have a great set of buns.

Here's another one..."Girl, you're like an overdue library book...you've got FINE written all over you."

"are you tired?"
"why?"
"because you've been running through my mind all night"

You know what would look good on you? Me! I got that one.:tsk:

Do you know the difference between a big mac and a BJ? No, Let's go to McDonalds.:thumbdown

And the one that deserved a slap but I laughed my ass off - After spilling a little of a drink I said, I missed my mouth. He said - I never would!:bustingup

A slap? I don't know, I'd think that a girl would find that hot :D