I'll take Covid in Floriduh for $100...or "Is DeSantis toast?"

[Happy]

Long-Term Dangers Of Experimental MRNA Shots

MONICA LOZANO



“Let’s start with a thought experiment: If an engineering design flaw exists and no one measures it, can it really injure people or kill them?” a Twitter user named Ehden writes. He goes on to discuss an overlooked aspect of the COVID mRNA shots, something called “codon optimization,” which virtually guarantees unexpected results.

Ehden explains:

“Trying to tell your body to generate proteins is hard for many reasons. One of them is the fact that when you try to run the protein information via ribosomes which process that code and generate the protein, it can be very slow or can get stuck during the process.

Luckily, scientists found a way to overcome this problem, by doing code substitution: instead of using the original genetic code to generate the protein, they changed the letters in the code so the code would be optimized. This is known as Codon Optimization.”

COVID Shots Use Codon Optimization

A codon consists of three nucleotides, and nucleotides are the building blocks of DNA. An August 2021 article in Nature Reviews Drug Discovery, addressed the use of codon optimization as follows:

“The open reading frame of the mRNA vaccine is the most crucial component because it contains the coding sequence that is translated into protein.

Although the open reading frame is not as malleable as the non-coding regions, it can be optimized to increase translation without altering the protein sequence by replacing rarely used codons with more frequently occurring codons that encode the same amino acid residue.

For instance, the biopharmaceutical company CureVac AG discovered that human mRNA codons rarely have A or U at the third position and patented a strategy that replaces A or U at the third position in the open reading frame with G or C. CureVac used this optimization strategy for its SARS-CoV-2 candidate CVnCoV …

Although replacement of rare codons is an attractive optimization strategy, it must be used judiciously. This is because, in the case of some proteins, the slower translation rate of rare codons is necessary for proper protein folding.

To maximize translation, the mRNA sequence typically incorporates modified nucleosides, such as pseudouridine, N1-methylpseudouridine or other nucleoside analogues. Because all native mRNAs include modified nucleosides, the immune system has evolved to recognize unmodified single-stranded RNA, which is a hallmark of viral infection.

Specifically, unmodified mRNA is recognized by pattern recognition receptors, such as Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich regions in mRNA and trigger the production of type I interferons, such as IFNα, that can block mRNA translation.

The use of modified nucleosides, particularly modified uridine, prevents recognition by pattern recognition receptors, enabling sufficient levels of translation to produce prophylactic amounts of protein.

Both the Moderna and Pfizer–BioNTech SARS-CoV-2 vaccines … contain nucleoside-modified mRNAs. Another strategy to avoid detection by pattern recognition receptors, pioneered by CureVac, uses sequence engineering and codon optimization to deplete uridines by boosting the GC content of the vaccine mRNA.”

According to Ehden, 60.9 percent of the codons in COVID shots have been optimized, equivalent to 22.5 percent of the nucleotides, but he doesn’t specify which shot he’s talking about, or exactly where the data came from.

That all mRNA COVID shots are using codon optimization to one degree or another is clear, however. A July 2021 article in the journal Vaccines specifically evaluates and comments on the Pfizer/BioNTech and Moderna mRNA shots, noting:

The design of Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations … The mRNA components of the vaccine need to have a 5′-UTR to load ribosomes efficiently onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and optimal stop codon for efficient translation termination.

Both 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. The replacement of uridine by N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ is more versatile in wobbling than U. Different optimizations can conflict with each other, and compromises would need to be made.

I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantage and disadvantage of each to facilitate future vaccine improvement. In particular, I point out a few optimizations in the design of the two mRNA vaccines that have not been performed properly.”

What Can Go Wrong?

One key take-home from the Nature Reviews Drug Discovery article cited above is that replacing rare codons “must be used judiciously,” as rarer codons can have slower translation rates and a slowed-down rate is actually necessary to prevent protein misfolding.

The spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage. To expect the COVID shot to not produce these kinds of effects would be rather naïve.
A (adenine) and U (uracil) in the third position are rare, and the COVID shots replace these A’s and U’s with G’s (guanine) or C’s (cytosine). According to Seneff, this switch results in a 1,000-fold greater amount of spike protein compared to being infected with the actual virus.

What could go wrong? Well, just about anything. Again, the shot induces spike protein at levels unheard of in nature (even if SARS-CoV-2 is a “souped up” manmade concoction), and the spike protein is the toxic part of the virus responsible for the most unique effects of the virus, such as the blood clotting disorders, neurological problems and heart damage.

So, to expect the COVID shot to not produce these kinds of effects would be rather naïve. The codon switches might also result in protein misfolding, which is equally bad news. As explained by Seneff in our previous interview:

The spike proteins that these mRNA vaccines are producing … aren’t able to go into the membrane, which I think is going to encourage it to become a problematic prion protein. Then, when you have inflammation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].

So, you’re going to get alpha-synuclein drawn into misfolded spike proteins, turning into a mess inside the dendritic cells in the germinal centers in the spleen. And they’re going to package up all this crud into exosomes and release them. They’re then going to travel along the vagus nerve to the brainstem and cause things like Parkinson’s disease.

So, I think this is a complete setup for Parkinson’s disease … It’s going to push forward the date at which someone who has a propensity towards Parkinson’s is going to get it.

And it’s probably going to cause people to get Parkinson’s who never would have gotten it in the first place — especially if they keep getting the vaccine every year. Every year you do a booster, you bring the date that you’re going to get Parkinson’s ever closer.”

Immune Dysfunction And Viral Flare-Ups

Other significant threats include immune dysfunction and the flare-up of latent viral infections, which is something Mikovits has been warning about. In our previous interview, she noted:

“We use poly(I:C) [a toll-like receptor 3 agonist] to signal the cell to turn on the type I interferon pathway, and because [the spike protein your body produces in response to the COVID shot] is an unnatural synthetic envelope, you’re not seeing poly(I:C), and you’re not [activating] the Type I interferon pathway.

You’ve bypassed the plasmacytoid dendritic cell, which combined with IL-10, by talking to the regulatory B cells, decides what subclasses of antibodies to put out. So, you’ve bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors …

A large part of Dr. [Francis] Ruscetti’s and my work over the last 30 years has been to show you don’t need an infectious transmissible virus — just pieces and parts of these viruses are worse, because they also turn on danger signals. They act like danger signals and pathogen-associated molecular patterns.

So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response out of control. It just cannot keep up with the myelopoiesis [the production of cells in your bone marrow]. Hence you see a skew-away from the mesenchymal stem cell towards TGF-beta regulated hematopoietic stem cells.

This means you could see bleeding disorders on both ends. You can’t make enough firetrucks to send to the fire. Your innate immune response can’t get there, and then you’ve just got a total train wreck of your immune system.”

We’re now seeing reports of herpes and shingles infection following COVID-19 injection, and this is precisely what you can expect if your Type I interferon pathway is disabled. That’s not the end of your potential troubles, however, as these coinfections could accelerate other diseases as well.

For example, herpes viruses have been implicated as a trigger of both AIDS and myalgic encephalomyelitis (chronic fatigue syndrome or ME-CFS). According to Mikovits, these diseases don’t appear until viruses from different families partner up and retroviruses take out the Type 1 interferon pathway. Long term, the COVID mass injection campaign may be laying the foundation for a rapidly approaching avalanche of a wide range of debilitating chronic illnesses.

Are COVID Shots Appropriately Optimized?

As noted in the Vaccines article cited earlier, the codon optimization in the Pfizer and Moderna shots could be problematic:

“As mammalian host cells attack unmodified exogeneous RNA, all U nucleotides were replaced by N1-methylpseudouridine (Ψ). However, Ψ wobbles more in base-pairing than U and can pair not only with A and G, but also, to a lesser extent, with C and U.

This is likely to increase misreading of a codon by a near-cognate tRNA. When nucleotide U in stop codons was replaced by Ψ, the rate of misreading of a stop codon by a near-cognate tRNAs increased.

Such readthrough events would not only decrease the number of immunogenic proteins, but also produce a longer protein of unknown fate with potentially deleterious effects …

The designers of both vaccines considered CGG as the optimal codon in the CGN codon family and recoded almost all CGN codons to CGG … [M]ultiple lines of evidence suggest that CGC is a better codon than CGG. The designers of the mRNA vaccines (especially mRNA-1273) chose a wrong codon as the optimal codon.”

The paper also points out the importance of vaccine mRNA to be translated accurately and not merely effectively, because if the wrong amino acids are incorporated, it can confuse your immune system and prevent it from identifying the correct targets.

Accuracy is also important in translation termination, and here it comes down to selecting the correct stop codons. Stop codons (UAA, UAG or UGA), when present at the end of an mRNA coding sequence signals the termination of protein synthesis.

According to the author, both Pfizer and Moderna selected less than optimal stop codons. “UGA is a poor choice of a stop codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines could be even worse,” she says.

What Health Problems Can We Expect To See More Of?

While the variety of diseases we may see a rise in as a result of this vaccination campaign are myriad, some general predictions can be made. We’ve already seen a massive uptick in blood clotting disorders, heart attacks and stroke, as well as heart inflammation.

More long term, Seneff believes we’ll see a significant rise in cancer, accelerated Parkinson’s-like diseases, Huntington’s disease, and all types of autoimmune diseases and neurodegenerative disorders.

Mikovits also suspects many will develop chronic and debilitating diseases and will die prematurely. At highest risk, she places those who are asymptomatically infected with XMRVs and gammaretroviruses from contaminated conventional vaccines. The COVID shot will effectively accelerate their death by crippling their immune function. “The kids that are highly vaccinated, they’re ticking time bombs,” Mikovits said in my May 2021 interview.

[crystalworks]

Here is a link to the original article which is much easier to read. Well, as easy as a read on the subject can be. https://www.naturalnews.com/2021-09-...rna-shots.html Though it appears that exact article is posted on a few alternative science websites. Not sure which would be the "original."

Not sure I would count that site among my list of reliable sources, but to each their own. Here is an article on Mike Adams, AKA "The Health Ranger" for anyone interested in the slant of the content on his website(s), including naturalnews.com. https://www.mcgill.ca/oss/article/qu...reality-online

[Happy]

I can guarantee most not getting vaccinated are not doing so because of Trump, or any other silly notion. There are very real concerns about using an experimental gene therapy for some.

How some completely ignore the fact, that some want to be completely sure what their putting in their bodies is completely irresponsible.

To say, “oh you’re a danger to public health, or you’re taking my freedoms away, or you’re political affiliation”, and so on is not even remotely addressing the real concerns some have about receiving the gene therapy.

For those who feel what the CDC, NIH, etc., spokesperson says is completely trustworthy, well great for them. Get in line. I do know though, that most in this country like to think for themselves.

I’ve noticed with some vaccinated individuals that they take a, “it’s my way, or the highway approach”. How about actually doing some real research on what you just put in your body. Because, some of the arguments here are extremely flimsy at best.

[Happy]

https://irp.nih.gov/accomplishments/...n-genetic-code

[crystalworks]

Originally Posted by Happy

I can guarantee most not getting vaccinated are not doing so because of Trump, or any other silly notion. There are very real concerns about using an experimental gene therapy for some.

How some completely ignore the fact, that some want to be completely sure what their putting in their bodies is completely irresponsible.

To say, “oh you’re a danger to public health, or you’re taking my freedoms away, or you’re political affiliation”, and so on is not even remotely addressing the real concerns some have about receiving the gene therapy.

For those who feel what the CDC, NIH, etc., spokesperson says is completely trustworthy, well great for them. Get in line. I do know though, that most in this country like to think for themselves.

I’ve noticed with some vaccinated individuals that they take a, “it’s my way, or the highway approach”. How about actually doing some real research on what you just put in your body. Because, some of the arguments here are extremely flimsy at best.

For sure Happy. As stated before, I respect those who are unsure about the vaccine and don't want to take it because of those concerns. Some group all non-vaccinators as evil Republican Trump thumpers. And I'm sure some of them are. What percentage? Who knows. It doesn't really matter.

If the vaccines are as effective as touted on a personal level, there is no need to mandate the vaccine to all.

I was simply posting above that I would not necessarily trust that article without cross checking it. Which is hard to do 100% as I don't have a degree in bio-engineering or access to a lab to personally test the vaccine. We all have to trust someone else at some time. If it has passed your scrutiny, then yes, absolutely use it to base your decision on. That's your right.

[Happy]

https://creativedestructionmedia.com...f-fda-meeting/

[Maruzo]

Originally Posted by crystalworks

Here is a link to the original article which is much easier to read. Well, as easy as a read on the subject can be. https://www.naturalnews.com/2021-09-...rna-shots.html Though it appears that exact article is posted on a few alternative science websites. Not sure which would be the "original."

Not sure I would count that site among my list of reliable sources, but to each their own. Here is an article on Mike Adams, AKA "The Health Ranger" for anyone interested in the slant of the content on his website(s), including naturalnews.com. https://www.mcgill.ca/oss/article/qu...reality-online

MRna is just one type of covid vaccine, albeit the most effective one at the moment.

Those who have concerns about mrna type of treatment can always find the numerous other vaccines like AZ, J&J, and at least 4 other vaccines from other countries (if they do become available here).

If my recollection is correct, AZ and J&J vaccines are created using the more traditional virus-based technology. Methodology that has been proven to be quite safe over time (translation: "long term") and with minimal side effects.

Citing your unwillingless to get vaccinated due to concerns for mrna? What's your excuse for not taking the other?

The very word "long term danger" means you won't know for a fact what that danger is until sufficient time has passed to be considered as "long term".

Any speculation now is simply that: speculation.

But I suppose people have based their health & safety decision on much less, all those who believed in Trump's cacamamy cures comes to mind.

Reminds me of this funny but sadly real tiktok video i saw a month ago: a bunch of protesters are chanting their disagreement with signing up for covid vaccination, they are saying that covid isn't a serious danger for the general public, that the overall rate of infection has not increased, in fact decreased as time move on. They say, if covid is so dangerous, why aren't the "homeless dead on the street", and none of them had their mask on (as they packed closely and protested).

Then a homeless guy casually walks by with his shopping cart and says: "That's coz I vaccinated, you dumb fuck."

https://twitter.com/i/status/1445566038855217158

Cracks me up.

[bcredliner]

Originally Posted by EODguy

The Spanish flu killed roughly the same amount of people but at the time we only had 1/3rd of the population so... NOT even close as deaths equaled 20% of the population.
More than 50,000,000 died worldwide. Masks were recommend and there were mandates requiring social distancing.The was no vaccination for the Spanish Flu. The following article outlines how we have repeated what took place then. The vaccination is the exception but just as then many resisted mandates and would not social distance. You will notice masks were also worn. The difference between then and now is we have vaccines. I don't think it matters how the percentages of death differ. The US has experienced 45,000,000 cases, 3,000,000 hospitalized and 750,000 deaths. Thus far almost half of the US is bound and determined to repeat the mistakes of the Spanish flu. Oh, and COVID is not over until it is over. https://www.cdc.gov/flu/pandemic-res...al-distancing/

The mRNA vaccines were a deadly failure in EVERY trial (20 years worth) until now and NONE of the test subjects survived long term, although most died of reactions shortly after injection.
As just one example, the flu vaccine is a mRNA vaccine. While the effectiveness varies from year to year it has not failed nor has it ever been deadly. https://www.cdc.gov/coronavirus/2019...ines/mrna.html

The Peoples Rights and freedom are NOT negated by the chance that you might catch covid19 from someone else. These vaccines either work or they don't.
The vaccines work. The other guidelines are also effective. Rights or freedom are not negated. Not getting vaccinated or not following the guidelines crosses the line of where rights and freedom end.

If it works than who gives a shit if they are around someone who is unvaccinated?

Vaccines are never 100% effective. There are breakthrough cases. The longer the pandemic the more likely the virus will mutate to a point the vaccine is less or completely ineffective. I want to get to new normal. Vaccination is the key to getting there.

If it doesn't work than the vaccinated are just as threatening to the vaccinated and unvaccinated. It's not rocket surgery it's just pure fear and ignorance.

The vaccine does work. Who is fearful and ignorant?

Going off of the stats for ALL age groups your risk of not recovering from covid19 is 0.3%, but if looking at it by age groups then people 65 and older have a 2.0% chance of dying and 85 and over roughly an additional 2.5% and those numbers are still lower since it's not a 100% chance that you will even catch it, but more like less than 50% based solely on the number of people who didn't pass it on to other members of their household who lived with them. (anecdotal evidence only)
I don't think percentages matter anymore and and anecdotal evidence is not evidence. It is using, in this case calculations, from too small a sample to accurately project the total.
In the United States the number of deaths in children is so low that it cannot even be considered a statistical anomaly (43) out of approximately 335,000,000 and every single one of those had a comorbidity such as severe asthma, leukemia or heart defects.

Over 700 have died. And it doesn't matter how they are medically compromised. At the time of the infection they were alive and might have lived to a ripe old age if not for COVID. The same is true of all age catagories. And that figure doesn't count those that have continuing problems after recovery.

Two basic things to understand....

1. Viruses mutate due to pressure of survival i.e. if it's not hard to survive in say one group but has a hard time in a different group the virus in the difficult group will mutate at a much higher rate whereas those in an easier environment will mutate much, much more slowly.

I am in the camp that viruses are not alive. They are proteins and cannot live outside of a host. In either case a virus mutates and the mutation can be more deadly and even cause the vaccines to be ineffective.
https://microbiologysociety.org/publ...t-is-life.html

2. DNA that is subjected to something like mRNA, viruses, radiation will at some point change or mutate. A perfect example is radiation. A person exposed to 50 rads at 18 years old has a very high chance of developing cancer, but a person exposed to 50 rads at the age 40 has a lower chance solely due to the number of times less the DNA (telomeres specifically) will reproduce before death.

mNRA viruses don't change DNA, radiation is something entirely different and does change DNA https://www.cdc.gov/coronavirus/2019...ines/mrna.html
Sent from my SM-A730F using Tapatalk

Based on the anecdotal .3 percent will die which I don't think is applicable only 250,000 more people will die in the US. Based on the current deaths per day rate of about 1300 the virus should be gone in about 6 months. With almost half the country unvaccinated and most of the country not following the guidelines that just isn't going to happen. I think it is a sure thing that there will be more variants. We were lucky that the vaccines are as effective on the Delta variants.

[Happy]

Originally Posted by crystalworks

For sure Happy. As stated before, I respect those who are unsure about the vaccine and don't want to take it because of those concerns. Some group all non-vaccinators as evil Republican Trump thumpers. And I'm sure some of them are. What percentage? Who knows. It doesn't really matter.

I think it’s an absurd argument on both sides. LoL.. “I am not getting vaccinated because I am a Trumper”. “You won’t get vaccinated because you’re a Trumper”. No wonder the USA is falling apart.

Originally Posted by crystalworks

If the vaccines are as effective as touted on a personal level, there is no need to mandate the vaccine to all.

Exactly!

Originally Posted by crystalworks

I was simply posting above that I would not necessarily trust that article without cross checking it. Which is hard to do 100% as I don't have a degree in bio-engineering or access to a lab to personally test the vaccine. We all have to trust someone else at some time. If it has passed your scrutiny, then yes, absolutely use it to base your decision on. That's your right.

Finally a forum member who gets it!

P.S. You have always understood.

[crystalworks]

Originally Posted by Maruzo

Citing your unwillingless to get vaccinated due to concerns for mrna? What's your excuse for not taking the other?

The very word "long term danger" means you won't know for a fact what that danger is until sufficient time has passed to be considered as "long term".

Me? My family got the mRNA from Pfizer. But I respect the decision of those who choose not get get vaccinated. Once again, excepting public schools.

Bottom line, people aren't dying at rates that scare people. So there will be those willing to risk not getting vaccinated.

Difference between you and me is, you call them idiots. I don't.